The role of male-derived factors in infertility now receives increasing prominence, as investigations focus more on the couple, rather than solely the female partner. Although there are many books on infertility, few devote themselves wholly to the male partner. Male Infertility redresses this balance by increasing awareness of both the causes and management of infertility in the male. This revised and updated edition contains new chapters covering urological disorders that may occur concomitantly with male infertility, such as testicular cancer, penile disorders and prostate cancer. A practical and clinical guide, Male Infertility enables clinicians to make quick and accurate diagnoses of the cause before pursuing the most appropriate treatment option to maximise the chances of conception. Of particular value to gynaecologists and andrologists, this text will be of great interest to any clinician working in the infertility clinic, as well as primary care practitioners and trainees.

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The new edition of this canonical text on male reproductive medicine will cement the book’s market-leading position. Practitioners across many specialties – including urologists, gynecologists, reproductive endocrinologists, medical endocrinologists and many in internal medicine and family practice – will see men with suboptimal fertility and reproductive problems. The book provides an excellent source of timely, well-considered information for those training in this young and rapidly evolving field. While several recent books provide targeted ‘cookbooks’ for those in a male reproductive laboratory, or quick reference for practising generalists, the modern, comprehensive reference providing both a background for male reproductive medicine as well as clinical practice information based on that foundation has been lacking until now. The book has been extensively revised with a particular focus on modern molecular medicine. Appropriate therapeutic interventions are highlighted throughout.

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Male accessory gland infection frequency in infertile patients with chronic …
Fifty consecutive patients with the following criteria were enrolled: (i) infertility; (ii) diagnosis of CBP; and (iii) diagnosis of IBS according to the Rome III criteria. The following two aged-matched control groups were also studied: infertile …
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Hope and strategies for couples dealing with male infertility If you or your partner is suffering from male infertility, you’re not alone. Millions of couples are struggling with this problem. About 40% of these couples have exclusively male infertility problems, while another 20% have both male and female infertility problems. Now, two leading experts, a urologist specializing in male infertility and a psychologist, team up to write the most complete guide available on male infertility. From the latest, state-of-the-art treatments to advice on how to handle the emotional aspects of male infertility, you’ll find out where to get the help you need. Overcoming Male Infertility also covers the psychological issues that are unique to men, and gives advice to women on helping their man through the trauma of infertility treatment–including how to get him to see a doctor in the first place.

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Male infertility is simply defined as the inability to produce healthy sperm. Although a man might be embarrassed to admit that he has a fertility problem, but it is equally important that he undergoes fertility testing. Male infertility is a highly manageable condition with current medical treatment. Male infertility is indicated when, after checking both partners, problems in reproductive function have been identified in the male partner.

Male infertility is the underlying reason for 40% of infertile couples using assisted reproduction technologies. Male infertility is caused by chronic prostatitis in 50-60% cases. Without effective treatment of this disease recovery of male fertility is unlikely.

Couples are generally advised to seek medical help if they are unable to achieve pregnancy after a year of unprotected intercourse. The doctor conducts a physical examination of both partners to determine their general state of health and to evaluate physical factors that may be causing infertility. Couples with antisperm antibodies should be referred to a reproductive endocrinologist for further evaluation and treatment.

Approximately 40% of reported cases of infertility are due to problems in the male; another 40% to problems in the female; the remaining 20% are of unknown cause or due to problems in both the male and female.

Sperm production is controlled by a series of hormones produced in a small gland called the pituitary. Most men have normal levels of these hormones but occasionally, the pituitary gland can malfunction and production of these hormones is affected. Spermatozoa ( sperm ) are relatively fragile cells and are easily damaged by a number of environmental and life style habits. Increased body temperature resulting from illness, prolonged periods of sitting in hot tubs, or tight clothing can affect sperm production and function.

Sperm require three months to develop and a semen analysis done today reflects conditions three months ago. One of the more common causes of male infertility is abnormal temperature increases in the testicles. Sperm count and motility are primarily bulk parameters, while newer measures address cell membrane integrity, sperm capacitation and ability to acrosome react as well as sperm-egg interaction. With the advent of in vitro fertilization, we can now directly assess sperm fertilizing ability. Sperm counts appear to differ by region. Temperature and climate may play some role in the differences seen from country to country and from year to year.

Zinc and folic acid are also great sperm builders. These additional nutrients to maca root and orange juice should all be taken in high-quality natural supplement form-as well as in diet form. Zinc deficiency can lead to reduced numbers of sperm and impotence in men, although the correlation between blood levels of zinc and sperm quality remains controversial. Reportedly, infertile men have lower levels of zinc in their semen, than men with normal fertility.

For those who are searching for natural ways to increase sperm and improve fertility, you may want to research and consider the following:

Lega-C was designed to increase fertility in men. While there can be more than one factor contributing to infertility, many of these factors can be successfully addressed with the use of herbs and vitamins. The herbs in the formula are used to increase the production, quality, and quantity in the areas of male fertility. The biggest successes have come from those who have combined herbs with the appropriate vitamin and mineral supplements. Many men seldom receive the essential vitamins and minerals that are pertinent to their reproductive health. Lega-C contains extracts of: Eleuthero Root, Tribulus Terrestris Fruit, Pygeum Bark, Horny Goat Weed Leaf and Astragalus Root.

Progentor IV is a natural solution to improve male responsiveness. It restores sustained ability and natural male performance. Those afflicted with cardiovascular disease, peptic ulcers, kidney malfunctions, or using tricyclic/anti-depressants should not use Yohimbe. Caution should be exercised when using anticoagulants such as Aspirin or Warfarin along with Ginkgo Biloba. Hypertension patients should not use large quantities of Ginseng as it can cause elevated blood pressure. Contains: Yohimbe Bark, Ginkgo Biloba Leaf, Horny Goat Weed, Ashwagandha Root, Eleuthero Root and Tribulus Terrestris Fruit.

SemenRX is an all natural supplement that increases not only the volume of the semen, but the way semen looks and is ejaculated from the penis. It promises more powerful orgasms and an increase in sexual desire and energy. Semen Trigonellae Foenum-Graecum or Fenugreek seed help reduce urinary glucose levels: Studies on diabetic animals have found fenugreek seed to help reduce urinary glucose levels. The seeds contain the alkaloid trogonelline, nicotinic acid and coumarin.

Semenax has been formulated with the exact blend and proportions to give the astonishing effects that you desired including an increase semen production. These astonishing effects include longer and more intense orgasms every time, bigger and more impressive loads of semen, superior ejaculation, whiter and more robust texture and appearance of semen, increased contraction strength, and overall improved sexual function and response. Semenax has consistently scored high points in comparison with the many male enhancement products available on the market.

Prostalex Plus is the natural solution for infertility due to prostitis. Prostalex Plus is an all-natural, non-prescription supplement that dramatically reduces an enlarged prostate and helps relieve uncomfortable, frequent and other related urination issues. The formula contains 11 hand-selected, high-quality ingredients that work together to restore proper prostate function and health. Prostalex Plus is a natural supplement that relieves discomfort from an enlarged prostate.

Information and statements regarding dietary supplements have not been evaluated by the Food and Drug Administration and are not intended to diagnose, treat, cure, or prevent any disease. Information contained within this site is intended solely for general educational purposes and is not intended nor implied to be a substitute for professional medical advice relative to your specific medical condition or question. Always seek the advice of your physician or other health provider for any questions you may have regarding your medical condition.

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Couples who notice that they have been failing to conceive a child may certainly need to see a doctor. The doctor may first examine the female but it doesn’t mean that the male partner is completely free of any possibility of infertility. As a matter of fact, statistics reveal that about 20% of couples who consult with physicians about their failure to conceive a child might discover that it’s the male partner who is infertile. Because of this it is not just the women who should learn about the potential factors that cause their infertility. The men too, particularly those who wish to have babies soon, must learn about the causes that can render them unable to impregnate their partners.

In finding out male infertility causes, doctors would usually require examinations on semen samples. A male individual, hence, who wishes to have himself diagnosed for possible infertility must first provide the health practitioner, usually a urologist, a sample of his own semen. Aside from semen examination though, the male may also be asked to have other series of tests, for instance blood work in order to ascertain hormonal levels. Conducting an ultrasound is also possible just like the post-ejaculatory urinalysis for them to find out if retrograde ejaculation is present.

Unlike females, it is much harder to determine the symptoms of infertility among males. However, there are conditions that can be considered as most likely factors for male infertility causes. The possibility for infertility is higher in a man who is in his forties and above. There are exceptional cases though, where men as old as sixty can continue to impregnate their fertile partners. Nonetheless, if a male individual has a advanced level of toxins in his body due to drinking too much alcohol and to smoking, the probability of infertility can be very high.

The most probable male infertility causes are usually based on the conditions of the sperm. If there is an absolute absence of sperm, a condition called azoospermia, the male certainly has nothing to fertilize the woman’s egg cell. Infertility can also be caused by low sperm count or oligospermia. The quantity of sperm cells isn’t the only factor for a man to fail in fertilizing a woman’s egg. If the sperm has an abnormal shape or if its movement toward the eggs runs into problems, infertility can also be possible. Of course, physical factors in the form of sexual dysfunctions and poor erection hinder the sperm from fertilizing the woman’s egg cell.

If the male infertility causes are found out, the doctor may recommend certain steps to mend the condition. If infertility is caused by infection, the doctor would naturally introduce a treatment method that would include the application of antibiotics. On the other hand, if the problem is triggered by a varicocele, a surgical operation is often necessary. However, infertility can simply be prompted by poor nutrition. In this regard, the male would only be advised to take supplements and eat certain foods rich with nutrients that can increase sperm count.

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In the past, we were made to believe that infertility is a condition that only occurs in female. But the recent science casts more enlightenment on myths that were thought to be facts, we now know for certain that infertility obviously appears even in the male patients.

In fact, we are to examine the recorded cases of infertility, details will show us that factors of infertility is divided almost equally among female and male factors. These constituting factors take 30% and another 30% are covered by the shared factors which itself covers the unknown infertility conditions. Depending on the problems that the patient presents, treatments will vary largely from medications to extensive case analysis that may incur surgeries and operations on the affected areas.

Say for example erectile dysfunction, the only obvious clinical representation for which one may base the diagnosis of the condition. (Note: Infertility is not a physical condition and most symptoms are only shade of a far greater problem that resides inside the male’s body.).

Erectile dysfunction can be readily treated with medications. But with more advanced signs of infertility in man, the ultimate treatment may lead both the patient and the physician to using assisted reproduction technologies which do not only address male factors causing infertility but may also help treat female infertility.

Normally, in several types of assisted reproduction technologies, male patients are asked to produce semen from which the sperm cells are gathered. There are many factors that will lead the techniques to either its success or its failure. One of which is the semen quality.

If the semen quality is workable for in-vitro fertilization (a form of assisted reproduction technology), it can fertilize along with female egg cells. This would commence all other methods that will follow after the semen and egg retrieval.

However, if the semen has overly low quality, it would be possible that the patients will be asked if they would want to adopt sperms from donors. If not, the procedure won’t continue at all. If they would agree then the cycle will be limited to the egg cell from the partner and sperm cells from another person.

Unfortunately, there exists no technology that will help increase the quality of the sperm cells of a specific person. The only thing that the medical science can do is to make the most out of the present condition the sperm quality may offer.

Male infertility is nearly hundred percent based on sperm problems. It may either be that the male patient develops poor sperm quality, low sperm count, or worse no sperm at all. Unfortunately enough, there is still no technique that may affect the condition of the sperm cells as presented by the patient. Instead, all treatments focus on how to make the most of the sperm cells that are under study.

In male infertility treatment, the female factors should also be taken seriously as these, in fact, largely contribute to the presence of the condition. For untreated male infertility, there is only less than 50% possibility that pregnancy will occur more specifically for cases that present semen quality as the main focus of the problem.

However, it is strange how the nature of semen quality fluctuation is not understood in the medical community. Often, the belief that the treatment is effective or ineffective depending on the variability of the treatment is misleading. Meanwhile, wide spectrum of male infertility treatments is still, for the present, has no scientific evidence to back up their effectiveness. This spectrum covers herbal treatments to hormonal treatment.

One of the simplest yet considered high-tech procedure in male infertility treatment is the artificial insemination of the sperm cells coupled with ovarian stimulation.

In-vitro fertilization, a method that is fastly becoming the ultimate option for nearly all couples who can afford the extensive treatment seem to offer a solution for infertility. Nonetheless, there are still no accurate parameters to predict the effectiveness of the treatment. In common cases, patients normally undergo 3 cycles before a possible conception is achieved. Aside from financial taxation, this infertility treatment can also exhaust the willingness of the couple to do the procedure for the 5th, 9th or who-can-guess how many more times.

Another option in aid of fertilization for poor sperm quality is the use of sperm donation. This is rarely the case though since men, with the high rate of sperm production is almost impossible of not creating semen. Nonetheless, for patients who are in need of this treatment, the assurance of success is high given the factor that the female is fertile.

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The Genetics of Male Infertility
In this book, twenty-one researchers and clinicians review the study of the genetics of male infertility, the tools available in t…

The Genetic Basis of Male Infertility (Results and Problems in Cell Differentiation)
Every year there are new and exciting developments in assisted human reproduction, but how much do we really know about the underl…

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I. Definition
Infertility is defined as inability of a couple to conceive after 12 months of unprotected sexual intercourse or can not carry the pregnancy to full term. It effects over 5 millions couple alone in the U. S. and many times more in the world, because of unawareness of treatments, only 10% seeks help from professional specialist. In fact, More than 40% of infertility of a couple is caused by male inability to fertilize. Diagnosis is a analytics approach, after initial consultation and medical history and personal information have been taken from a patient or couple. The main objective conventional diagnosis is to find the causes of infertility, but unfortunately, it has less than 1% successful rate. We will try to give you the definitions of type of diagnosis used .

I. Medical history and physical exams
Before reading the definition of types of diagnosis, you may want to know briefly what information is recorded on your personal file
I. General medical history
1. Any miscarriage, previous pregnancies and abortion.
2. Any ectopic pregnancy
3. Any previous surgery
4. Have you now on HRT.
5. Use of conceptive method, type of use
6. Any reproductive chronic pain including STD. urinary tract infection ad chronic diseases.
7. Medication you are taking now
8. Any medication of your mother during pregnancy to rule out infertility caused by birth defect
9. Your lifestyle.

II. Physical Exam
a) Testicle related including injure, childhood testicle illness and abnormal in birth
b) Age of puberty
c) Number of previous sexual partners
d) Question related to ejaculation and impotence
e) Do you have child with other women
f) Have you ever contacted and treated with sexual transmitted diseases
g) Hot bath
h) Smoking and drugs abuse
i) Expose to radiation
j) workplace hazard
k) Medication may influence your sexual organs.
l) Other general exam depending to your specialist (herbalist or others)

III. Male Infertility Diagnosis
1. Acrosome reaction test
After the sample is taken your fertility specialist exam the acrosome reaction of your sperms to see how your sperm penetrate the female egg, how the enzymes (acrosome then acrosin released from the sperm head ) in sperm work through tough coating of the eggs and fgertilized it. The purpose of this test is to diagnosis the sperm acrosome then acrosin to see hoe these enzyme help to break tough surface of the egg. If not it may be the cause of infertility and specific treatment is required. It happens only 5% of infertility male population.

2. Antisperm antibody
An antisperm antibody test as defined as a test to look for abnormal function of immune system antibodies that fight against a male’s sperm in blood, vaginal fluids, or semen. With a substance added to the sample sperm, the test will tell whether the sperm is affected by proteins of the immune system or not.

3. Biochemical analysis
The study of the chemical substances and vital processes occur in male testicle such as the concentration of white blood cells, the level of fructose in the semen, and the volume, pH, and liquefaction.

4. Computer-Assist semen analysis
The sample of sperm is scanned in to the computer pre store program to show how the sperm quality, quantity, shape and movement. Since any small change of the computer may produce a significant change in sperm calculation, therefore any abnormal sperm count should be confirmed by manual count.

5. Hemizona assay
Hemizona assay is the analysis to compare sample sperm of the male to the sperm of the fertilized male by splitting the mature and normal egg into 2 half. 1/2 is tested by sample sperm and the other half is tested by fertilized male sperm.

6. Hormone evaluation
Hormonal evaluation is a study to measure the levels of certain hormones produced by your body such as levels of FSH and testosterone which are involved directly in sperm production. The test will only be used if the semen of sperm analysis comes back with low density of sperm or your specialist suspects that hormone imbalance is the cause of infertility.

7. Human zona pellucida binding test
The testes help to exam how the sperm bind to outer layer of the egg including hemizona assay.

8. Hypoosmotic swelling test (HOST)
hypoosmotic swelling test (HOST) is the test used to identify sperm membrane for structure integrity by examining how the sperm tails react to special sugar and salt. Only healthy sperm can react in that circumstance.

9. Pene trak
Pene trak is the test for 90 minutes to check the movement of sperm through a normal and friendly mucus in the test tube.

10. Peroxidase staining
It is a test to check for infection by differentiating white blood cell from the immature sperm.

11.Post-coital/cervical mucus test
It is a test to see how friendly the mucus of the cervix toward the sperm invasion a few days before and after ovulation. The result can be determined after
a) Male partner sperm with female partner cervical mucus
b) Male partner sperm with healthy mucus
c) Known healthy sperm with female partner mucus
d) Known healthy sperm with known healthy muscle

12. Sperm penetration assay (hamster test)
Sperm penetration test only is needed if the normal semen test can not determine the sperm penetration ability then hamster eggs with the ouster membrane has been stripped off are used in place of female eggs because of it’s structural similarity to human eggs. After the sperm and hamster eggs have incubated for three hours, the eggs are checked for sperm penetration. Any percentage over 10 % is considered normal and potential for fertilization. Since it is used eggs other than human being, good sperm penetration rate in hamster test does not guarantee 100% of positive result in human.

13.Sperm-Ubiquitin tag immunoassay (SUTI)
Sperm-Ubiquitin tag immunoassay ignores other sperm attributes and focus solely on sperm’s ubiquitin because ubiquitin is considered as a universal marker of any sperm abnormalities including sperm damage and sperm defective, thereby reducing some unnecessary treatments.

14. Semen analysis
A semen analysis is usually the first test for all infertility male , it helps to measure the amount of semen a man produces and determines the quantity and quality of sperm such as size, shape. movement and PH level in the sample.
a) Normal form sperm
Ovary head, single tail with intact midsection and an uncoiled.
b) Abnormal heads
Head of sperm if too big or too small and other than ovary head.
c) Abnormal tails
Coil, broken, bent tail and other than single tail.
d) Immature gen cells
Since white blood cells and white gen cells have a very similar appearance and structure, it is up to the specialist to make sure that the present is immature gen cells and not white blood cells.
e) Vital staining
It is the analysis to see the percentage of dead sperm compare to lice one.

15. Scrotal sonography
Scotal sonography is used to evaluate the testicle disorder and surrounding organs including prostate gland, epididymis, an absent or undescended testicle and any testicle abnormality.

16. Testicle biopsy
A small sample is taken and tested for the ability of sperm producing cellsl in normal cells production. This test is necessary if the infertility male is found to have no sperm in semen, normal sex levels of hormone and abnormal sperm with unknown cause. The risk of the test may cause testicle damage.

17. Vasography
Vasography is a Radiographic study of the vas deferens. It helps to determine if the vas deferens is blocked or not and the reason of such blockage. In this study, if there is large amount of sperm containing fluid presented when the vas deferens is open, it indicates there is a block appeared in the vesicle end of the vas deferens. If there is no fluid presented, the procedure continue until the cause of blockage is found, if there is one.

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Infertility is a couple’s inability to conceive a child after 12 months of unprotected sex. It is widely assumed that infertility has more to do with women rather than men, however it is not so. Estimates suggest that 30% of infertility is caused by male factors, another 30% is caused by female factors and the remaining 40% is caused by a combination of female and male factors. Men also suffer from infertility due to genetic reasons, lifestyle, hormonal imbalance, and age.

Let’s take a look at the cause, diagnosis, and possible treatments available.

Rapid urbanization has changed the way men eat, drink, and sleep and that has taken a toll on their health. Consumption of alcohol, smoking, drugs, unhealthy eating patterns, stress and obesity are believed to be the common causes for infertility. Being overweight or underweight may also prove to be risk factors. A recent study also suggests that external factors like pollution can also infiltrate male reproductive organs. However, you can reduce the risk by a proper exercise and a healthy diet.
Some of the factors that play an important role in male infertility are: Sperm Motility, Sperm Morphology, and Sperm Count. Usually a semen analysis is conducted to diagnose the cause which includes the following:

Sperm motility:

Sperm motility is the ability of sperms to move towards the egg which results in its fertilization. Sperm which do not properly swim will not reach the egg in order to fertilize it.

Sperm count:

Sperm count is the quantity of sperms or cells, the more the sperms more are the chances of normal pregnancy. A healthy sperm count should total about 20 million sperm per milliliter and the normal semen volume per ejaculation is 2 ml. Azoospermia is a condition in which there is complete absence of sperm. It can also be congenital. Correctible causes must be found and treated. Even then if there are no sperm in the ejaculate, sperm can often be harvested and used to achieve fertilization.

Sperm morphology:

Sperm morphology refers to the size and shape (form) of an individual sperm which is evaluated during semen analysis. According to WHO manual of 1989, morphology is considered normal if it is around 30% or more.

Deficiency of any of these factors can result in infertility.

If you are facing infertility that does not means that your parental hopes have become extinct. Infertility is a common problem among men and fortunately these days, treatment options are available. If the cause is diagnosed at an early stage your chances of success are more as age plays an important role in infertility treatment. Modern scientific technologies like ART, ICSI, and IUI have made the treatment easy. However, this treatment can be very expensive and can burn a hole in your pocket. Today inexpensive methods are also available without any compromise on the treatment and methodology.

Always remember that infertility can be cured like any other disease and it does not mean that your masculinity is at stake. By being fit you can fight infertility.

If you have been through or experiencing infertility,come share your experiences with us.

Author of the article is an IVF Fertility, infertility specialist and runs fertility centre that provides the best affordable quality infertility,fertility treatments with advanced reproductive technologies like IVF,ART, GIFT, ZIFT, TET, ICSI,donor egg, surrogate and surrogacy services for all nationalities.

Rotunda-The Center for Human Reproduction

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